hepatic sinusoid

Morphological observation on pathological changes of hepatic sinusoid in rats with alcoholic hepatopathy

酒精性肝病大鼠肝窦病理改变的形态学观察

It also improves microcirculation of liver and prevent capillarity of hepatic sinusoid .

改善肝脏微循环，抑制肝窦毛细血管化；

Mechanism and prevention of hepatic sinusoid epithelial cell injuried by ischemia and reperfusion in rats

大鼠肝血窦内皮细胞缺血再灌注损伤机理及防护的研究

Electron microscope were used to assess the ultrastructural lesions of the endothelial cells of hepatic sinusoid .

电镜观察各组大鼠肝窦内皮细胞的超微结构变化，并比较其损伤程度。

There were more inflammatory cells infiltrated in hepatic sinusoid at 6 hours after trauma .

肝脏镜下创伤休克后6h肝窦内出现较多炎性细胞浸润。

Hepatic sinusoid is distinct , and hemocyte and endothelial cell can be seen on the hepatic sinusoid wall .

肝血窦明显，可见窦壁中的血细胞和内皮细胞。

Objective To study the mechanism and prevention of hepatic sinusoid epithelial cell ( HSEC ) injury caused by ischemia and reperfusion in rats .

目的研究肝血窦内皮细胞（SEC）缺血再灌注损伤机理及防护方法。

Results Ballooning degeneration of the liver cells and fibrosis around hepatic sinusoid was scarce in mild NASH cases and increased in moderate to severe cases .

结果轻度NASH患者中气球样变肝细胞及窦周纤维化少见，中-重度患者中气球样变肝细胞及窦周纤维化，随着病理分级升高而加重；

Hepatic sinusoid , as specialized capillary network , its reconstruction in the live generation process involves in the cell division of vessel endothelial cell and other cell types .

肝窦是特化的毛细血管网，肝再生过程中，肝血窦的重构涉及到血管内皮细胞及其它细胞的分裂增殖。

Objective : To observe changes in liver function in the early stage after thermal injury and potential role of hepatic sinusoid endothelial cells ( SEC ) in development of liver dysfunction .

目的：观察大鼠烫伤后早期肝功能变化及肝窦内皮细胞（SEC）在其中的作用。

The number of finger microvilli of hepatocyte 's surface in hepatic sinusoid in hibernation period is fewer significantly than that in initial post-hibernation .

冬眠期肝血窦内肝细胞表面的微绒毛数目明显少于出眠初期。

The histology examination demonstrated that a lot of C-Fe @ CN-CN was accumulated among liver cells and in the hepatic sinusoid in the magnetic field .

靶区肝组织切片显示，C-Fe@CN-CN在磁场作用下聚集于肝细胞间和肝窦中。

The fenestra of hepatic sinusoid endothelial cells disappeared , basement membrane continued and ( thickened ,) and Disse diastem collagen fiber increased .

肝窦内皮细胞窗孔消失，基膜连续并增厚，狄氏间隙胶原纤维增多。

Conclusion A large number of platelet piled in the hepatic sinusoid and they released lots of their granules , platelet count , adhesive and aggregative function decreased during hepatic ischemia reperfusion .

结论肝缺血再灌注过程中，血小板数量减少，血小板积聚于肝窦状隙并大量脱颗粒，其粘附、聚集功能下降。

The proliferation , migration , adherence and alignment until eventually the formation of the whole hepatic sinusoid must be related to the changes of the plasma membrane proteins on the hepatic sinusoid endothelial cell .

内皮细胞的增殖、迁移、粘着、排列以至最后形成完整的肝血窦必定涉及到肝窦内皮细胞质膜蛋白质的变化。

HE staining showed necrosis of hepatocytes , thickened blood vessel wall of portal area with infiltration of lymphocytes and monocytes , hyperaemia in central vein and hepatic sinusoid , hyperplasia of Kupffer 's cell ;

苏木精伊红染色发现二氧化硫染毒可引起肝实质细胞坏死，汇管区血管壁增厚并伴有淋巴细胞和单核细胞浸润，中央静脉以及肝窦充血，库普弗细胞增生；

Conclusion Ballooning degeneration of the liver cells and fibrosis around the hepatic sinusoid have important value in differential diagnosis of mild from moderate to severe NASH , and correct histological grading benefits clinical intervention and prognostic evaluation of NASH .

结论病理组织学诊断对于鉴别轻度NASH及中重度NASH有重要价值，正确的NASH分级有助于预后判断及临床干预。

The optical microscope results manifested : after endotoxin , Hepatic sinusoid extended , hepatocyte was mutation and dead , the inflammation cell appeared in portal area , and the pathological changes of the liver histology had obviously improved in Jie Du Hua Yu Fang groups .

光镜结果显示：内毒素组肝窦扩张，肝细胞嗜酸性变及坏死，汇管区见炎性细胞浸润，解毒化瘀方组肝组织学病变明显好转。

So it was concluded that decreasing the content of NO in blood plasma , inhibiting the excessive expression of CD31 、 CD62p on platelet membrane and CD54 in endothelial vessels , hepatic sinusoid may be the molecular mechanism of Replenishing Qi and Promoting Blood Circulation .

由此推测，降低血浆NO含量，抑制血小板CD31、CD62p的高表达，抑制心肺血管内皮细胞、肝窦内皮细胞表面CD54的高表达是其发挥益气活血作用的分子机理。

The liver became atrophy and diminution , porta hepatic and hepatic sinusoid swelled , there was hyperemia in tela ; the color of cells darken , cytoplasm reduced , nucleus cracked and disappeared , cells turned to vacuolization , the volume of the cells was significantly smaller than before .

肝脏萎缩变小，肝门肝窦增大，组织内充血；肝细胞颜色变深，细胞质减少，细胞核破碎消失，细胞呈现空泡化，细胞体积显著变小。

Compared with other endothelia cells , SEC has not septum and base membrane ( BM ) below , thus nutrition and oxygen can transport freely between hepatic cells and liver sinusoid blood .

与其它内皮细胞不同的是，SEC的窗孔无隔膜，而且内皮下也无基底膜（BM）存在，肝细胞可与肝窦血液中的营养物质和氧进行自由交换。

In group B , along with the time going on , the histopathologic changes gradually aggravated , the changes included different degrees hepatic congestion , configuration destroy of hepatic sinusoid , degeneration and necrosis of liver cell ;

B组随着移植后时间的延长，肝组织病变逐渐加重，出现不同程度的肝淤血、肝窦结构破坏、肝细胞变性及坏死；

Observation of histology : hepatic lobule architecture in the normal group was clear and hepatic sinusoid argyrophilic fiber in the normal group was porous .

组织学观察：正常组大鼠肝小叶结构清晰，肝窦网状纤维疏松。

The tissue structure of the liver mainly included hepatic lobule and portal area . Central vein , hepatocyte tube and hepatic sinusoid were found in hepatic lobule .

肝脏的组织结构由肝小叶和门管区构成，肝小叶由中央静脉、肝细胞管和肝窦组成，门管区包括小叶间胆管、小叶间动脉和小叶间静脉，还有淋巴组织分布。

As one of hepatic non-parenchymal cells , sinusoidal endothelial cells ( SECs ) constitute the wall of hepatic sinusoid , receive the blood flow mechanical stimulation directly and maintain the normal hepatic microcirculation .

肝窦内皮细胞（Sinusoidalendothelialcells，SECs）作为肝脏非实质细胞之一，是肝窦壁的组成细胞，直接接受血流等力学刺激作用，其结构与功能可维持正常的肝脏微循环。